Correction: Global analysis of host response to induction of a latent bacteriophage
نویسندگان
چکیده
Correction After the publication of this work [1], we became aware that the legends for Figures 2, 3 and 4 were not in the correct order. The legends should be as follows: Figure 2: Escherichia coli lambda lysogen DNA and average transcript levels after treatment with 10 J/m2 UV light. The x-axis is the position of genes on the E. coli chromosome. The E. coli origin is at the 0 position on the x-axis. The lambda integration site attB is indicated by the vertical line. The y-axis is the log ratio of treated to untreated cells. A). Average transcription (100 bins) along the E. coli chromosome at 20, 40, 60 minutes after exposure to UV light. B). Ratio of DNA 60 minutes after treatment with UV light relative to DNA of untreated cells. Figure 3: Functional categorization of E. coli genes during lambda phage induction. Histograms count number of genes significantly up-regulated (black) or downregulated (grey) at each time interval. Genes were grouped according to the NCBI COG classification scheme [49]. Categories with an (*) were enriched in down-regulated genes (Fisher exact test, false discovery rate < 0.05): carbon catabolism, cell processes, cell structure, central metabolism energy metabolism, and transport. Figure 4: A) Diagram of the linear (integrated) lambda phage genome, color-coded by lifecycle stage (blue = lysogenic, yellow = early lytic, red = late lytic). B) (wild type phage) and C) (Lambda-P27): gene expression ratios during prophage induction are shown relative to an untreated "mock induction" control and log2 transformed. Genes arranged by order on the lambda genome.
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